胡燚[yì]，教授，博士生导师，微生物与生物技术药物学教研室主任。

国家重点研发计划项目首席科学家，江苏省高校“青蓝工程”中青年学术带头人，bevictor伟德国际1946官网第三届学术委员会委员。获bevictor伟德国际1946官网“名师名导百人计划”、 “师德十佳”、“南工精英九思奖”、“张家港市政府奖教金”、“泰兴产业学院奖教金”等奖励。作为主要参与人员获2020年中国粮油学会科学技术奖二等奖，2024年中国轻工业联合会科技进步奖二等奖。

教育经历：

2002/02-2005/03：浙江大学，有机化学，博士

1996/09-1999/03：浙江大学，物理化学，硕士

1992/09-1996/07：浙江大学，化学，学士

工作经历：

2016/02-----至今：bevictor伟德国际1946官网，伟德victor1946网站，教授

2023/04-2023/08：新加坡国立大学，CSC高级访问学者

2012/12-2013/12：The Scripps Research Institute，访问学者

2005/05-2016/02：bevictor伟德国际1946官网，生物与制药工程学院，讲师-副教授-教授

2001/02-2002/02：杭州精彩化工有限公司，研发工程师

1999/03-2001/02：浙江新和成股份有限公司，研发工程师

研究方向：

(1) 酶催化性能强化分子改造研究。

(2) 生物-化学组合催化技术在药物及其中间体、功能性营养化学品等高端精细化学品绿色合成中的应用研究。

(3) 酶法治理有机污染物研究。

(4) 低廉生物质资源的高值化生物炼制。

(5) 精细化学品合成工艺开发。

代表性科研项目：

(1) 国家重点研发计划项目，低廉生物质资源高值化炼制关键技术与产业示范（2021YFC2103800），2021/12-2025/11，主持。

(2) 国家自然科学基金面上项目，基于酶分子理性设计协同载体设计双向调控酶-载体动态适配构型的高效固定化机制研究（22678286），2027/1-2030/12，主持。

(3) 国家自然科学基金面上项目，功能性离子液体修饰有机-无机纳米复合材料固定化酶研究（22178174），2022/1-2025/12，主持。

(4) 国家自然科学基金面上项目，基于分子模拟的功能性离子液体化学修饰脂肪酶分子改造研究（21676143），2017/1-2020/12，主持。

(5) 国家自然科学基金青年基金项目，功能化离子液体修饰介孔材料在酶固定化中的应用研究（20906049），2010/1-2012/12，主持。

(6) 国家“863”计划重大项目子课题，左旋帕罗醇的生物不对称合成技术（2011AA02A209），2011/1-2015/12，主持。

(7) 国家科技支撑计划重点项目子课题，低浓度乙醇制乙烯工艺技术开发（2006BAE02B04），2006/12-2009/12，主持。

(8) 中国石化科技开发项目，熔盐循环等温固定床数值模拟及中试实验研究（L411003），2011/7-2013/12，主持。

(9) 企业委托开发项目，植物源胆固醇合成工艺开发，2023/5-2024/5，主持。

(10) 企业委托开发项目，植物源维生素D3的绿色合成工艺开发，2025/5-2026/5，主持。

2020年以来代表性论文：

(1) Yu Zhang, Bingqian Zheng, Jiaxiang Du, Zhiheng Chen, Zihan Zhang, Qingqing Liu, Yutai Fan, Zhen Gao, Weiyi Zheng, Yi Hu*, Binbin Nian*. Synergistic evolution of key-region flexibility maintenance and global scaffold rigidification enhances lipase performance for vitamin E succinate synthesis. Food Research International, Accepted. (一区TOP)

(2) Yiran Han, Zhiheng Chen, Hao Fang, Yi Hu*, Binbin Nian*. Rational design of hydrophobic deep eutectic solvents tunes the catalytic pocket of lipase for the sustainable synthesis of structural lipids. Food Research International, Accepted. (一区TOP)

(3) Bingling Liang, Zhiheng Chen, Hao Fang, Yu Zhang, Qingqing Liu, Yi Hu*, Binbin Nian*. Development of novel catalytic deep eutectic solvent for esterification and elucidation of dynamic solvent-enzyme-substrate adaptability. Bioresource Technology, 2026, 461, 135517. (一区TOP)

(4) Wei Zhang, Ziyi Li, Fan Li, Jian Wang, Zeping Lu, Yong-Xing Zhang*, Yi Hu*. Amino acid ionic liquid functionalized magnetic interface-induced directional enrichment and immobilization of active conformations of lipase. Journal of Agricultural and Food Chemistry, 2026, 74(30): 23684-23697. (一区TOP)

(5) Wei Zhang, Huaiyu Li, Heng Li, Jian Wang, Yongxing Zhang*, Yi Hu*. Ionic liquid-modified MOFs as a dual-functional platform for enhanced laccase stability and 2,4-dichlorophenol degradation. Chemical Engineering Science, 2026, 333: 124301. (一区TOP)

(6) Zihan Zhang, Yu Zhang, Qingqing Liu, Wanqing Song, Yi Hu*, Binbin Nian*. Efficient biomanufacturing of vitamin E succinate in non-aqueous media via synergistic computational evolution and immobilization of lipase. Bioresource Technology, 2026, 458: 135069. (一区TOP)

(7) Qingqing Liu, Jiaxiang Du, Weihang Lin, Xuanling Zhang, Yi Hu*, Binbin Nian*. Tailoring the enzymatic microenvironment in bifunctional macroporous resins: Synergizing interfacial activation and structural rigidity for process-intensified biocatalysis in extreme solvents. Chemical Engineering Journal, 2026, 543, 178164. (一区TOP)

(8) Ke-Xu Ren, Ye-Jian Li, Xu Yang, Hang-Cheng Li, Yao-Dong Li, Zi-Yan Wang, Long-Jia Fan, Yi Hu*, Hua-Jin Xu*. Rapid alternating polarity as an approach for electrocatalytic synthesis of remote meta-C−H alkenylation. Organic Letters, 2025, 27(42): 11708-11713. (一区TOP)

(9) Huajin Xu, Zhoulong Fan, Binbin Nian, Chenhao Gu, Shuojie Shen, Wei Zhang, Yi Hu*, Jinquan Yu*. Achieving mono-selective palladium(II)-catalysed C–H activation of arenes with protein ligands. Nature Catalysis, 2025, 8: 948-956.  (一区TOP)

(10) Yiran Han, Hao Fang, Xiaoyu Nie, Xuanling Zhang, Zeping Lu, Binbin Nian, Yi Hu*, Wenjun Cheng*. Potential applications of lipases rational design in the synthesis of medium- and long-chain triglycerides: Current advances and perspectives. Food Chemistry, 2025, 493(part 4): 146049. (一区TOP)

(11) Mingjie Xie, Jiaxiang Du, Miaohang Jia, Xiaoyu Nie, Xuanling Zhang, Yi Hu*, Binbin Nian*. Computer-aided techniques in the engineering of enzyme binding pockets: New perspectives and frontiers. Journal of Agricultural and Food Chemistry, 2025, 73(33): 20600-20615. (一区TOP)

(12) Liran Ji, Jiaxiang Du, Wei Zhang, Zeping Lu, Binbin Nian*, Yi Hu*. Dual role of ionic liquid modified β-Cyclodextrin in dynamic conformational regulation and substrate enrichment for improved lipase immobilization. Carbohydrate Polymers, 2025, 364: 123786. (一区TOP)

(13) Wei Zhang, Hai Liu, Zeping Lu, Liran Ji, Binbin Nian, Yi Hu*. Ionic liquid interface modification of magnetic carboxymethyl cellulose-immobilized lipase: Improvement of lid and tunnel structures to enhance stability and catalytic performance. Chemical Engineering Journal, 2025, 507: 160647. (一区TOP)

(14) Xiaoman Wang, Qianqian Chen, Jinhang Zhou, Yi Hu*, Shengqing Ye*, Jie Wu*. Electrochemical synthesis of alkenylsulfonates from alkynes, NaHSO3, and alcohols. Chinese Journal of Chemistry, 2025, 43(3): 292—296. (一区TOP)

(15) Yuan Qi, Zihan Zhang, Yanjiao Liu, Chunyi Liang, Wenya Chong, Binbin Nian*, Yi Hu*. Lipase substrate anchoring dynamics guided the rational design of novel deep eutectic solvents for glucose ester synthesis. Journal of Agricultural and Food Chemistry, 2024, 72(42): 23401-23410. (一区TOP)

(16) Zihan Zhang, Yifei Zhang, Yanjiao Liu, Chunyi Liang, Binbin Nian*, Yi Hu*. Amino-alkyl group dual-functional modification synergistically regulated lipase-carrier interactions and enhanced phytosterol ester synthesis efficiency. Journal of Agricultural and Food Chemistry, 2024, 72(42): 23345-23354. (一区TOP)

(17) Wenya Chong, Zihan Zhang, Zhongyu Li, Shuaiqi Meng, Binbin Nian*, Yi Hu*. Hook loop dynamics engineering transcended the barrier of activity-stability trade-off and boosted the thermostability of enzymes. International Journal of Biological Macromolecules, 2024, 278(Part 4): 134953. (一区TOP)

(18) Yuan Qi, Mei Chen, Tongtong Jin, Wenya Chong, Zihan Zhang, Binbin Nian*, Yi Hu*. Computer-aided engineering of lipases solvent tolerance enhanced their applications in sugar esters synthesis: State of the art. Trends in Food Science & Technology, 2024, 144: 104323. (一区TOP)

(19) Wenya Chong, Yuan Qi, Liran Ji, Zihan Zhang, Zeping Lu, Binbin Nian*, Yi Hu*. Computer-aided tunnel engineering-a promising strategy for improving lipase applications in esterification reactions. ACS Catalysis, 2024, 14(1): 67-83. (一区TOP)

(20) Shuojie Shen, Yaodong Li, Ye Ge, Xu Yang, Linhu Li, Huajin Xu*, Yi Hu*. Ligand promoted Pd-catalyzed high para-selective C–H Olefination. Organic Letters, 2023, 25(51): 9092-9096. (一区TOP)

(21) Zeping Lu, Mei Chen, Tongtong Jin, Binbin Nian*, Yi Hu*. Immobilization of Candida antarctica lipase B on ILs modified CNTs with different chain lengths: Regulation of substrate tunnel "Leucine gating". International Journal of Biological Macromolecules, 2023, 248: 125894. (一区TOP)

(22) Chenghao Gu, Zhen Zhang, Shuojie Shen, Huajin Xu*, Yi Hu*. A cheap and efficient oxidant (n-Bu)₄NNO₃-enabled C(sp²)– and C(sp³)–H olefination at room temperature. Organic Letters, 2023, 25(15): 2622-2626. (一区TOP)

(23) Binbin Nian, Yi Hu*. Anionic H-bonds improve the disorganization of starch in metal chloride hydrate-natural deep eutectic solvent. Carbohydrate Polymers, 2022, 298, 120150. (一区TOP)

(24) Xiang Qiu, ShuShu Wang, Hongbo Suo, Huajin Xu, Yi Hu*. Co-immobilization of laccase and ABTS onto amino-functionalized ionic liquid-modified magnetic chitosan nanoparticles for pollutants removal. Journal of Hazardous Materials, 2021, 401, 123353. (一区TOP)

(25) Xiang Qiu, Ying Wang, Yu Xue, Wenxuan Li, Yi Hu*. Laccase immobilized on magnetic nanoparticles modified by aminofunctionalized ionic liquid via dialdehyde starch for phenolic compounds biodegradation. Chemical Engineering Journal, 2020, 391, 123564. (一区TOP)

(26) Hongbo Suo, Lili Xu, Yu Xue, Xiang Qiu, Hongyue Chen, He Huang*, Yi Hu*. Ionic liquids-modified cellulose coated magnetic nanoparticles for enzyme immobilization: Improvement of catalytic performance. Carbohydrate Polymers, 2020, 234, 115914. (一区TOP)

(27) Yajie Fu, Zeping Lu, Xiaolong Ma, Ke Fang, Xinyi He, Huajin Xu, Yi Hu*. One-pot cascade synthesis of benzopyrans and dihydropyrano[c]chromenes catalyzed by lipase TLIM. Bioorganic Chemistry, 2020, 99, 103888. (一区TOP)

系方式：

025-58139396，huyi@njtech.edu.cn